Customer Service | Help | FAQ | Report a Data Error | About
:
Login
Tip: To use Evernote for note taking…

PEP-Web Tip of the Day

Evernote  is a general note taking application that integrates with your browser.  You can use it to save entire articles, bookmark articles, take notes, and more. It comes in both a free version which has limited synchronization capabilities, and also a subscription version, which raises that limit. You can download Evernote for your computer here. It can be used online, and there’s an app for it as well.

Some of the things you can do with Evernote:

  • Save search-result lists
  • Save complete articles
  • Save bookmarks to articles

 

For the complete list of tips, see PEP-Web Tips on the PEP-Web support page.

Malcolm-Smith, S. Thomas, K.G. Ipser, J. Stein, D. van Honk, J. Solms, M. (2013). Opioid Function is Dysregulated Subsequent to Early Social Trauma: Healthy Young Adults' Response to a Buprenorphine Challenge. Neuropsychoanalysis, 15(2):127-143.

(2013). Neuropsychoanalysis, 15(2):127-143

Opioid Function is Dysregulated Subsequent to Early Social Trauma: Healthy Young Adults' Response to a Buprenorphine Challenge

Susan Malcolm-Smith, Kevin G. F. Thomas, Jonathan Ipser, Dan Stein, Jack van Honk and Mark Solms

Panksepp's separation-distress model of depression posits that endogenous opioid systems become dysregulated subsequent to early social trauma and that this dysregulation constitutes a risk factor for depression. We tested an aspect of this model by recruiting medically and psychiatrically healthy young adults (N = 32) who differed on one key criterion—exposure to early social trauma. In terms of core affective personality traits as measured by the Affective Neuroscience Personality Scales (ANPS), those not exposed to early social trauma scored significantly higher on SEEKING; the groups did not differ on SADNESS. Importantly, the groups also responded differently to a low-dose opioid challenge (0.2 mg sublingual buprenorphine vs. placebo). Buprenorphine administration had little effect on emotion in controls, but it reduced experience of both positive and negative emotion in trauma-exposed participants. The latter also showed a significant negative bias in social cognition that was not attenuated by buprenorphine, whereas controls were more likely to show a positive bias on buprenorphine (relative to trauma-exposed participants). The groups' differing responses to buprenorphine suggest that their opioid systems are functioning differently. These data constitute preliminary proof of concept for a key aspect of the model. Further investigation of the role of endogenous opioids in depression subsequent to early social trauma is warranted.

[This is a summary or excerpt from the full text of the book or article. The full text of the document is available to subscribers.]

Copyright © 2018, Psychoanalytic Electronic Publishing, ISSN 2472-6982 Customer Service | Help | FAQ | Download PEP Bibliography | Report a Data Error | About

WARNING! This text is printed for personal use. It is copyright to the journal in which it originally appeared. It is illegal to redistribute it in any form.