Customer Service | Help | FAQ | PEP-Easy | Report a Data Error | About
:
Login
Tip: To use the Information icon…

PEP-Web Tip of the Day

The Information icon (an i in a circle) will give you valuable information about PEP Web data and features. You can find it besides a PEP Web feature and the author’s name in every journal article. Simply move the mouse pointer over the icon and click on it for the information to appear.

For the complete list of tips, see PEP-Web Tips on the PEP-Web support page.

Panksepp, J. (2016). Etiological pathways toward autism and diversities of treatments: from unimodal to multidimensional approaches. Commentary on “An integrative model of autism spectrum disorder: ASD as a neurobiological disorder of experienced environmental deprivation, early life stress, and allostatic overload” by William M. Singletary, M.D.. Neuropsychoanalysis, 18(1):19-23.

(2016). Neuropsychoanalysis, 18(1):19-23

Etiological pathways toward autism and diversities of treatments: from unimodal to multidimensional approaches. Commentary on “An integrative model of autism spectrum disorder: ASD as a neurobiological disorder of experienced environmental deprivation, early life stress, and allostatic overload” by William M. Singletary, M.D.

Jaak Panksepp

The diversity of factors that may contribute to autism is enormous. Some lead to therapeutic ideas, most do not. Our own early work focused on possible endogenous opioid excesses in the brain, which lead to the use of low doses of naltrexone (LDN, 0.25 mg/kg, every other day, orally administered). The history of such an intervention is summarized. This strategy, even at much lower doses (such as ∼0.5 mg per day orally), has now been claimed to have benefits for a large variety of bodily problems, including diverse pains, multiple sclerosis, and a variety of other problems. Here I focus on our early experiences in treating autism with LDN, and wonder how it relates to Singletary's fascinating, wide-ranging therapeutic experiences. His interventions, which likely facilitated neuroplasticity (as suggested by the work Singletary reviews by Molly Helt and others), promoted remarkable improvements in seven-year-old Larry, a high-functioning Asperger's child. As Larry progressed from self-centered social aloneness toward the capacity to love with multimodal neuroplasticity-inspired treatments, I wonder if LDN might speed the journey with children like him.

[This is a summary excerpt from the full text of the journal article. The full text of the document is available to journal subscribers on the publisher's website here.]

Copyright © 2019, Psychoanalytic Electronic Publishing, ISSN 2472-6982 Customer Service | Help | FAQ | Download PEP Bibliography | Report a Data Error | About

WARNING! This text is printed for personal use. It is copyright to the journal in which it originally appeared. It is illegal to redistribute it in any form.