Customer Service | Help | FAQ | PEP-Easy | Report a Data Error | About
Tip: To sort articles by Rankā€¦

PEP-Web Tip of the Day

You can specify Rank as the sort order when searching (it’s the default) which will put the articles which best matched your search on the top, and the complete results in descending relevance to your search. This feature is useful for finding the most important articles on a specific topic.

You can also change the sort order of results by selecting rank at the top of the search results pane after you perform a search. Note that rank order after a search only ranks up to 1000 maximum results that were returned; specifying rank in the search dialog ranks all possibilities before choosing the final 1000 (or less) to return.

For the complete list of tips, see PEP-Web Tips on the PEP-Web support page.

Malcolm-Smith, S. Thomas, K.G. Ipser, J. Stein, D. van Honk, J. Solms, M. (2013). Opioid Function is Dysregulated Subsequent to Early Social Trauma: Healthy Young Adults' Response to a Buprenorphine Challenge. Neuropsychoanalysis, 15(2):127-143.

(2013). Neuropsychoanalysis, 15(2):127-143

Opioid Function is Dysregulated Subsequent to Early Social Trauma: Healthy Young Adults' Response to a Buprenorphine Challenge

Susan Malcolm-Smith, Kevin G. F. Thomas, Jonathan Ipser, Dan Stein, Jack van Honk and Mark Solms

Panksepp's separation-distress model of depression posits that endogenous opioid systems become dysregulated subsequent to early social trauma and that this dysregulation constitutes a risk factor for depression. We tested an aspect of this model by recruiting medically and psychiatrically healthy young adults (N = 32) who differed on one key criterion—exposure to early social trauma. In terms of core affective personality traits as measured by the Affective Neuroscience Personality Scales (ANPS), those not exposed to early social trauma scored significantly higher on SEEKING; the groups did not differ on SADNESS. Importantly, the groups also responded differently to a low-dose opioid challenge (0.2 mg sublingual buprenorphine vs. placebo). Buprenorphine administration had little effect on emotion in controls, but it reduced experience of both positive and negative emotion in trauma-exposed participants. The latter also showed a significant negative bias in social cognition that was not attenuated by buprenorphine, whereas controls were more likely to show a positive bias on buprenorphine (relative to trauma-exposed participants). The groups' differing responses to buprenorphine suggest that their opioid systems are functioning differently. These data constitute preliminary proof of concept for a key aspect of the model. Further investigation of the role of endogenous opioids in depression subsequent to early social trauma is warranted.

[This is a summary or excerpt from the full text of the book or article. The full text of the document is available to subscribers.]

Copyright © 2021, Psychoanalytic Electronic Publishing, ISSN 2472-6982 Customer Service | Help | FAQ | Download PEP Bibliography | Report a Data Error | About

WARNING! This text is printed for personal use. It is copyright to the journal in which it originally appeared. It is illegal to redistribute it in any form.