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(1954). Archives of Neurology and Psychiatry. LXIX, 1953: Study of Adrenocortical Physiology in Normal and Schizophrenic Men. Hudson Hoagland, Gregory Pincus, Fred Elmadjian, Louise Romanoff, Harry Freeman, Justin Hope, James Ballan, Austin Berkeley, and James Carlo. Pp. 470-485.. Psychoanal Q., 23:472-473.
Psychoanalytic Electronic Publishing: Archives of Neurology and Psychiatry. LXIX, 1953: Study of Adrenocortical Physiology in Normal and Schizophrenic Men. Hudson Hoagland, Gregory Pincus, Fred Elmadjian, Louise Romanoff, Harry Freeman, Justin Hope, James Ballan, Austin Berkeley, and James Carlo. Pp. 470-485.

(1954). Psychoanalytic Quarterly, 23:472-473

Archives of Neurology and Psychiatry. LXIX, 1953: Study of Adrenocortical Physiology in Normal and Schizophrenic Men. Hudson Hoagland, Gregory Pincus, Fred Elmadjian, Louise Romanoff, Harry Freeman, Justin Hope, James Ballan, Austin Berkeley, and James Carlo. Pp. 470-485.

Hoagland and his colleagues compared adrenocortical physiology in normal and schizophrenic men by studying two groups, one of seventy-two normal men and one of sixty-seven schizophrenic men patients in the Worcester State Hospital. Each group was divided into a younger (age twenty to thirty-nine) and an older (age forty to sixty) group and various indices of adrenocortical function were tested. The reactions were studied at rest, after subjection to three stress tests, and after injection of corticotropin.

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At rest both the older and younger schizophrenic patients showed evidence of hyperadrenalism or hypoadrenalism. The older schizophrenic patients, like the younger ones, showed less adrenal response to the stress tests and to the injected corticotropin than did normal subjects. However, the older schizophrenic patients were considerably more responsive to the corticotropin than were the younger patients. Adrenal responses to stress are in general therefore subnormal in schizophrenic patients. The relatively greater unresponsiveness to corticotropin in the younger patients may be due to there being more acute cases in that group, corresponding to a state of exhaustion of the adaptation syndrome. On the other hand, this finding may be explained as a genetically determined factor, which is itself predisposing to the development of the psychosis, or else it may be due to a larger concentration in the younger patients, as compared with the older ones, of enzymes which inactivate corticotropin.

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Article Citation

(1954). Archives of Neurology and Psychiatry. LXIX, 1953. Psychoanal. Q., 23:472-473

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